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From Annihilus Wiki
You should be able to add an exclusion for the Anni Folder in windows defender rather than turning the whole thing off I had to do that with another game and it worked fine. https://media.discordapp.net/attachments/577284406025388065/768877431461249044/unknown.png?width=400
Afterwards you can fix your installation by right-clicking the "Options" button above the description box, and go to Verify Installation.